A Data Driven Approach to Profile Potential SARS-CoV-2 Drug Interactions Using TylerADE

We use a data driven approach on cleaned adverse drug reaction database to determine the severity of several covid-19 combinations currently under investigation. further examine their safety for vulnerable populations such as individuals 65 years and older. Our key findings include 1. hydroxychloroquine/chloroquine are associated with increased event versus other already not recommended by NIH treatment guidelines, 2. hydroxychloroquine/azithromycin lower among older populations, 3. lopinavir/ritonavir had toddlers 4. combination azithromycin, hydroxychloroquine tocilizumab is safer than its component drugs. While our does consider efficacy, it can help prioritize clinical trials focusing those lowest thus increase potential options patients.